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KMID : 0357920100440010077
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Korean Journal of Pathology
2010 Volume.44 No. 1 p.77 ~ p.82
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The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix
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Jeong Joo-Hyeon
Cho Hyun-Yee
Kim Na-Rae
Chung Dong-Hae
Park Sang-Hui
Ha Seung-Yeon
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Abstract
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Background: The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution.
Methods:In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546).
Results: Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV. Single infection occurred most commonly (72.1% of women). HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11. The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05).
Conclusions: HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years.
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KEYWORD
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Human papillomavirus, Oligonucleotide array sequence analysis, Cytology, Cervix uteri
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